human pcsk9 protein (ACROBiosystems)
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human pcsk9 protein
Human Pcsk9 Protein, supplied by ACROBiosystems, used in various techniques. Bioz Stars score: 95/100, based on 18 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/human+pcsk9+protein/Human+PCSK9+Protein%2C+His+Tag/pmc12517242-122-10-13
Average 95 stars, based on 18 article reviews
Human Pcsk9 Protein, supplied by ACROBiosystems, used in various techniques. Bioz Stars score: 95/100, based on 18 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/human+pcsk9+protein/Human+PCSK9+Protein%2C+His+Tag/pmc12517242-122-10-13
Average 95 stars, based on 18 article reviews
human pcsk9 protein - by Bioz Stars,
2026-09
95/100 stars
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1) Product Images from "PCSK9 and coronary atherosclerosis progression beyond LDL‐cholesterol in coronary artery disease patients"
Article Title: PCSK9 and coronary atherosclerosis progression beyond LDL‐cholesterol in coronary artery disease patients
Journal: European Journal of Clinical Investigation
doi: 10.1111/eci.70083
Figure Legend Snippet: Association between circulating levels of plasma PCSK9 with lipid (Total‐C, LDL‐C and HDL‐C) and inflammatory (IL6, MMP9 and ICAM1) profiles of study patients.
Techniques Used: Clinical Proteomics
Figure Legend Snippet: Association of PCSK9 plasma levels and plaque progression. In univariate and multivariate models, data are depicted as β coefficients with 95% CIs for the annual change in plaque volume from baseline to follow‐up coronary CTA.
Techniques Used: Clinical Proteomics
Figure Legend Snippet: RNA‐sequencing results (A) Molecular pathway enrichment by STRING linking circulating PCSK9‐related gene dataset with KEGG databases; (B) PCSK9 and MMP9 plasma levels together with annual change of Necrotic Core and Fibrous PVs divided according to presence of PCSK9 gene expression in whole blood; (C) Functional annotation of PCSK9‐related genes according to GO Biological Processes. The 20 most significant biological processes are shown. The GeneRatio indicates how many PCSK9‐related genes included in the analysis were annotated to the specific GO biological process. GO terms were filtered for adjusted p ‐value <.01; (D) Visual combination of genes with related biological processes for enhanced graphical representation of functional categories related to innate immunity.
Techniques Used: RNA Sequencing, Clinical Proteomics, Gene Expression, Functional Assay
Figure Legend Snippet: In vitro study. (A) HUVECs were treated with PCSK9 (.25–5 μg/mL) for 4 h and RT‐PCR was performed with specific primers for VCAM‐1, ICAM‐1, and RPL13a; (B) ICAM‐1 and VCAM‐1 surface exposure in HUVEC treated with PCSK9 (.25–5 μg/mL) overnight. At the end of the incubation time, VCAM‐1 and ICAM‐1 surface exposure was quantified by EIA. Values are mean ± SD of optical density arbitrary units (AU) at 405 nm; (C) HUVECs were treated with PCSK9 (.25–5 μg/mL) for 4 h and RT‐PCR was performed with specific primers for MCP‐1, IL6, IL8 and RPL13a.
Techniques Used: In Vitro, Reverse Transcription Polymerase Chain Reaction, Incubation
Related Articles
Purification:Article Title: PCSK9 is a critical regulator of the innate immune response and septic shock outcome Article Snippet: The culture medium for the duration of the experiment was 80% DMEM (Invitrogen, 11965-065) and 20% human plasma from pooled healthy donors. .. Addition of PCSK9 Three hours before LPS treatment, cells were treated with purified recombinant Article Title: Lipopolysaccharide Is Cleared from the Circulation by Hepatocytes via the Low Density Lipoprotein Receptor Article Snippet: Data analysis was performed using Kaluza Analysis 1.3 software (Beckman Coulter). .. In separate experiments, 24 hours after siRNA transfection cells were treated with 3 μg/mL purified Article Title: Lipopolysaccharide Is Cleared from the Circulation by Hepatocytes via the Low Density Lipoprotein Receptor. Article Snippet: Data analysis was performed using Kaluza Analysis 1.3 software (Beckman Coulter). .. In separate experiments, 24 hours after siRNA transfection cells were treated with 3 μg/mL purified Article Title: PCSK9 is a critical regulator of the innate immune response and septic shock outcome Article Snippet: Data analysis was performed using Kaluza Analysis 1.3 software (Beckman Coulter). .. Three hours before LPS treatment, cells were treated with purified recombinant Recombinant:Article Title: PCSK9 is a critical regulator of the innate immune response and septic shock outcome Article Snippet: The culture medium for the duration of the experiment was 80% DMEM (Invitrogen, 11965-065) and 20% human plasma from pooled healthy donors. .. Addition of PCSK9 Three hours before LPS treatment, cells were treated with purified recombinant Article Title: Lipopolysaccharide Is Cleared from the Circulation by Hepatocytes via the Low Density Lipoprotein Receptor Article Snippet: Data analysis was performed using Kaluza Analysis 1.3 software (Beckman Coulter). .. In separate experiments, 24 hours after siRNA transfection cells were treated with 3 μg/mL purified Article Title: Lipopolysaccharide Is Cleared from the Circulation by Hepatocytes via the Low Density Lipoprotein Receptor. Article Snippet: Data analysis was performed using Kaluza Analysis 1.3 software (Beckman Coulter). .. In separate experiments, 24 hours after siRNA transfection cells were treated with 3 μg/mL purified Article Title: PCSK9 is a critical regulator of the innate immune response and septic shock outcome Article Snippet: Data analysis was performed using Kaluza Analysis 1.3 software (Beckman Coulter). .. Three hours before LPS treatment, cells were treated with purified recombinant Article Title: Modulation of vascular endothelial inflammatory response by proprotein convertase subtilisin-kexin type 9. Article Snippet: Background and Aims: Endotoxins carried within LDL are cleared from the circulation via hepatic LDL receptor (LDLR)-mediated endocytosis.. Proprotein convertase subtilisin-kexin type 9 (PCSK9) reduces this clearance by down-regulating LDLR density on hepatocytes.. In addition to hepatocytes, vascular endothelial cells also express receptor targets of PCSK9, including LDLR. Control:Article Title: PCSK9 is a critical regulator of the innate immune response and septic shock outcome Article Snippet: The culture medium for the duration of the experiment was 80% DMEM (Invitrogen, 11965-065) and 20% human plasma from pooled healthy donors. .. Addition of PCSK9 Three hours before LPS treatment, cells were treated with purified recombinant Article Title: PCSK9 is a critical regulator of the innate immune response and septic shock outcome Article Snippet: Data analysis was performed using Kaluza Analysis 1.3 software (Beckman Coulter). .. Three hours before LPS treatment, cells were treated with purified recombinant Transfection:Article Title: Lipopolysaccharide Is Cleared from the Circulation by Hepatocytes via the Low Density Lipoprotein Receptor Article Snippet: Data analysis was performed using Kaluza Analysis 1.3 software (Beckman Coulter). .. In separate experiments, 24 hours after siRNA transfection cells were treated with 3 μg/mL purified Article Title: Lipopolysaccharide Is Cleared from the Circulation by Hepatocytes via the Low Density Lipoprotein Receptor. Article Snippet: Data analysis was performed using Kaluza Analysis 1.3 software (Beckman Coulter). .. In separate experiments, 24 hours after siRNA transfection cells were treated with 3 μg/mL purified Expressing:Article Title: PCSK9 and coronary atherosclerosis progression beyond LDL-cholesterol in coronary artery disease patients. Article Snippet: .. HUVEC were stimulated with .25, 1, 2.5 or 5 μg/mL Article Title: PCSK9 and coronary atherosclerosis progression beyond LDL‐cholesterol in coronary artery disease patients Article Snippet: .. HUVEC were stimulated with .25, 1, 2.5 or 5 μg/mL |
